Serotonin is a neurotransmitter produced naturally by the body from the essential amino acids L-Tryptophan and 5-HTP (5-hydroxytryptophan).  5-HTP is produced commercially by extraction from the seeds of the African plant Griffonia simplicifolia or other plant sources.  In the central nervous system, serotonin is involved in the regulation of sleep, mood, appetite, temperature balance, sexual behaviour and pain sensation.  Other cells outside the brain, such as platelets, make and use serotonin.  The brain can only use that which is produced in the brain, as serotonin cannot pass the brain barrier.

The transport of L-tryptophan across the brain barrier can be inhibited by stress and lack of vitamin B6.  5-HTP is the active intermediate metabolite between L-Tryptophan (sourced as an amino acid in protein) and serotonin.  About 70% of oral dosing penetrates the blood stream and it can be taken with food (unlike L-Tryptophan).  5-HTP readily crosses the blood brain barrier, not requiring a transport molecule as does L-Tryptophan.

5-HTP can be used as nutrient support to help regulate normal body function when a deficiency of the neurotransmitter serotonin my be evident.  In this way it may be possible to improve outcomes which the health system seeks. Consult first with your medical adviser if you are using medication.